The Development of Next Generation Architectures for -N-Heterocyclic Carbene Pincer Ligands

Author

Tyler Owen Howell

Issuing Body

Mississippi State University

Advisor

Hollis, T. Keith

Committee Member

Rowland, Gerald

Committee Member

Emerson, Joseph P.

Date of Degree

8-15-2014

Document Type

Graduate Thesis - Open Access

Major

Chemistry

Degree Name

Master of Science

College

College of Arts and Sciences

Department

Department of Chemistry

Abstract

Methodologies for expanding the architectural diversity of -N-heterocyclic carbene (NHC) pincer ligand precursors and transition metal complexes have been developed for the production of more efficient catalyst, which will be employed in the synthesis of pharmaceuticals. An efficient route for the synthesis and isolation of bis-1,3-(3'-aryl-N-heterocycl-1'-yl)arenes has been established, and preliminary data for metalation and transmetalation of a N, N'-diaryl imidazolium salt has been acquired. Additionally, a proficient methodology for the synthesis of mixed, unsymmetrical -NHC pincer ligand precursors has been discovered, and preliminary data for mixed, unsymmetrical transition metal complexes is also included. These methodological expansions will lead to more efficient catalyst that decrease the expenditure of energy required for the synthesis of pharmaceuticals, thus making their synthesis more favorable for the environment and their price more affordable for consumers.

URI

https://hdl.handle.net/11668/20691

Comments

N-heterocyclic carbenes||unsymmetrical imidazolium salts||N-heterocyclic aryl salts||Pincer Ligands

Recommended Citation

Howell, Tyler Owen, "The Development of Next Generation Architectures for -N-Heterocyclic Carbene Pincer Ligands" (2014). Theses and Dissertations. 4314.
https://scholarsjunction.msstate.edu/td/4314