The Effect of Bmp-13 on the Chondroinduction of Mesenchymal Stem Cells

Author

Hilary Wynne Zelenka

Issuing Body

Mississippi State University

Advisor

Elder, Steve

Committee Member

Swiderski, Cyprianna

Committee Member

Cooley, James

Committee Member

Liao, Jun

Date of Degree

5-12-2012

Document Type

Graduate Thesis - Open Access

Major

Agricultural and Biological Engineering

Degree Name

Master of Science

College

College of Engineering

Department

Department of Agricultural and Biological Engineering

Abstract

Articular cartilage is a smooth, white connective tissue that covers and protects the ends of long bones to allow for a smooth, frictionless surface on which to glide for easy movement. Once the tissue is damaged, articular cartilage lacks a direct blood supply, which results in a limited ability to repair itself. This study explores the effect of the growth factor BMP-13 on the chondroinduction of primary human bone marrow-derived mesenchymal stem cells. The results demonstrate the limited ability of BMP-13 to exert a strong chondroinductive effect on human bone marrow-derived MSCs. However, the results do indicate that BMP-13 has the ability to sustain chondroinduction to a certain extent for up to 18 days following initiation by 3 days of exposure to TGF-β3. Results are encouraging for future work that involves growth factor influence on MSCs in articular cartilage tissue engineering.

URI

https://hdl.handle.net/11668/17784

Comments

growth factors||mesenchymal stem cells||tissue engineering||cartilage

Recommended Citation

Zelenka, Hilary Wynne, "The Effect of Bmp-13 on the Chondroinduction of Mesenchymal Stem Cells" (2012). Theses and Dissertations. 4331.
https://scholarsjunction.msstate.edu/td/4331