Date of Degree
Graduate Thesis - Open Access
Agricultural and Biological Engineering
Master of Science
College of Engineering
Department of Agricultural and Biological Engineering
Articular cartilage is a smooth, white connective tissue that covers and protects the ends of long bones to allow for a smooth, frictionless surface on which to glide for easy movement. Once the tissue is damaged, articular cartilage lacks a direct blood supply, which results in a limited ability to repair itself. This study explores the effect of the growth factor BMP-13 on the chondroinduction of primary human bone marrow-derived mesenchymal stem cells. The results demonstrate the limited ability of BMP-13 to exert a strong chondroinductive effect on human bone marrow-derived MSCs. However, the results do indicate that BMP-13 has the ability to sustain chondroinduction to a certain extent for up to 18 days following initiation by 3 days of exposure to TGF-β3. Results are encouraging for future work that involves growth factor influence on MSCs in articular cartilage tissue engineering.
Zelenka, Hilary Wynne, "The Effect of Bmp-13 on the Chondroinduction of Mesenchymal Stem Cells" (2012). Theses and Dissertations MSU. 4331.