Advisor

Elder, Steve

Committee Member

Swiderski, Cyprianna

Committee Member

Cooley, James

Committee Member

Liao, Jun

Date of Degree

1-1-2012

Document Type

Graduate Thesis - Open Access

Major

Agricultural and Biological Engineering

Degree Name

Master of Science

College

College of Engineering

Department

Department of Agricultural and Biological Engineering

Abstract

Articular cartilage is a smooth, white connective tissue that covers and protects the ends of long bones to allow for a smooth, frictionless surface on which to glide for easy movement. Once the tissue is damaged, articular cartilage lacks a direct blood supply, which results in a limited ability to repair itself. This study explores the effect of the growth factor BMP-13 on the chondroinduction of primary human bone marrow-derived mesenchymal stem cells. The results demonstrate the limited ability of BMP-13 to exert a strong chondroinductive effect on human bone marrow-derived MSCs. However, the results do indicate that BMP-13 has the ability to sustain chondroinduction to a certain extent for up to 18 days following initiation by 3 days of exposure to TGF-β3. Results are encouraging for future work that involves growth factor influence on MSCs in articular cartilage tissue engineering.

URI

https://hdl.handle.net/11668/17784

Comments

growth factors||mesenchymal stem cells||tissue engineering||cartilage

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