Theses and Dissertations
Issuing Body
Mississippi State University
Advisor
Wise, Dwayne A.
Committee Member
Downer, Donald N.
Committee Member
Boyle, John A.
Date of Degree
8-11-2007
Document Type
Graduate Thesis - Open Access
Major
Biological Sciences
Degree Name
Master of Science
College
College of Arts and Sciences
Department
Department of Biological Sciences
Abstract
A non-microtubule-based spindle matrix has been observed in Drosophila melanogaster meiotic and somatic cells. This matrix comprises the proteins: Skeletor, Megator and Chromator, which localize to the nuclear periphery and chromosomes at prophase and to the microtubule spindle during mitosis and meiosis. This matrix might play a role in nuclear organization and microtubule assembly and stabilization. It is important to determine the presence or absence of this matrix in other species in order to compare form and function to that in Drosophila. These matrix proteins were studied in both normally dividing cells and cells in which division was disrupted. Our evidence suggests that a spindle matrix exists in meiocytes and embryos of the cricket, Acheta domesticus, and in a mammalian cell line established from Chinese hamster ovary cells. We report the results of our studies on the spindle matrix in invertebrate and mammalian cells and discuss implications of these findings.
URI
https://hdl.handle.net/11668/17822
Recommended Citation
Chambers, Melissa Gwen, "The Role of a Non-Microtubule-Based Spindle Matrix in Eukaryotic Cellular Division" (2007). Theses and Dissertations. 4624.
https://scholarsjunction.msstate.edu/td/4624