The Role of Otolin-1 in Cardiac Matrix Remodeling following Myocardial Infarction

Author

Courtney Anne Cates

Issuing Body

Mississippi State University

Advisor

Lindsey, Merry L.

Committee Member

Elder, Steven H.

Committee Member

Simpson, C. LaShan

Committee Member

Stewart Jr., James A.

Committee Member

Cathcart, Thomas P.

Date of Degree

5-17-2014

Document Type

Graduate Thesis - Open Access

Major

Biomedical Engineering

Degree Name

Master of Science

College

James Worth Bagley College of Engineering

Department

Department of Agricultural and Biological Engineering

Abstract

Otolin-1 is a collagenous, C1q domain-containing extracellular matrix protein that has been identified and characterized in the inner ear. Recently, mass spectrometry analysis of left ventricular cardiac tissue detected a peptide of Otolin-1. Experimental analysis confirms Otolin-1 is an insoluble protein present in the left ventricular extracellular matrix whose expression decreases dramatically post-myocardial infarction beginning at day 5 post-MI. The protein is localized to the gap junctions of cardiac myocytes, and depletion of protein levels in the infarcted region of the left ventricle shows strong association with ventricular dimensions, observed via echocardiography.

URI

https://hdl.handle.net/11668/18187

Recommended Citation

Cates, Courtney Anne, "The Role of Otolin-1 in Cardiac Matrix Remodeling following Myocardial Infarction" (2014). Theses and Dissertations. 4640.
https://scholarsjunction.msstate.edu/td/4640