Theses and Dissertations

Issuing Body

Mississippi State University


Prabhu, Rajkumar

Committee Member

Williams, Lakiesha N.

Committee Member

Feugang, Jean M.N.

Committee Member

Baumgartner, Wes

Date of Degree


Original embargo terms


Document Type

Graduate Thesis - Open Access


Biomedical Engineering

Degree Name

Master of Science


James Worth Bagley College of Engineering


Department of Agricultural and Biological Engineering


Incurring high economic cost due to medical imaging modalities, there is a need for a low-cost, on site, diagnostic screening tool for the early detection of Traumatic Brain Injury (TBI). We hypothesize that patients with TBI will exhibit temporal and spatial gradient dynamics in the thermal signature on the surface of the skin, and that these dynamics reflect the inflammatory process. Hence, we implemented far-infrared (FIR) thermography using a blunt TBI rat model to analyze changes in the external, surface temperature gradient as an indication of internal inflammation. Results show a consistent increase in average surface temperature after 0.5 days of recovery post-impact. The trend in average surface temperature decreases after 1 day of recovery with a continual decline observed after a 4-day recovery. After 7 days of recovery, the average surface temperature begins to increase with a substantial surge seen 14 days post-impact. The trend appears to correlate well with the inflammatory process.