Theses and Dissertations
Issuing Body
Mississippi State University
Advisor
Johnson, Christopher N.
Committee Member
Bishop, G. Reid
Committee Member
Emerson, Joseph P.
Committee Member
Fitzkee, Nicholas C.
Date of Degree
12-10-2021
Document Type
Graduate Thesis - Open Access
Major
Chemistry
Degree Name
Master of Science (M.S.)
College
College of Arts and Sciences
Department
Department of Chemistry
Abstract
Calmodulin is a prevalent calcium sensing protein found in all cells. Three genes exist for calmodulin and all three of these genes encode for the exact same protein sequence. Recently mutations in the amino acid sequence of calmodulin have been identified in living human patients. Thus far, patients harboring these mutations in the calmodulin sequence have only displayed an altered cardiac related phenotype. Calcineurin is involved in many key physiological processes and its activity is regulated by calcium and calmodulin. In order to assess whether or not calcineurin contributes to calmodulinopathy (a pathological state arising from dysfunctional calmodulin), a comprehensive search of relevant literature has been performed. Herein, the physiological roles of calcineurin and consequences of dysfunction have been reviewed for literature focused on the heart.
Recommended Citation
Williams, Ryan B., "A review of calcineurin biophysics with implications for cardiac physiology" (2021). Theses and Dissertations. 5344.
https://scholarsjunction.msstate.edu/td/5344
Included in
Amino Acids, Peptides, and Proteins Commons, Biochemistry Commons, Biophysics Commons, Enzymes and Coenzymes Commons, Molecular Biology Commons