Mississippi State University
Seo, Keun Seok
Date of Degree
Graduate Thesis - Open Access
Master of Science (M.S.)
College of Arts and Sciences
Department of Biological Sciences
Streptococcus pneumoniae is an asymptomatic colonizer of the upper respiratory tract as well as an opportunistic pathogen. Colonization is prerequisite to causing disease in a host, and it often involves formation of biofilms. There are currently two vaccines available against pneumococcus, both of which focus on preventing invasive disease by targeting the polysaccharide capsule of the most invasive serotypes. We hypothesized that by using membrane proteins expressed during the biofilm state, we can formulate an effective vaccine against colonization which would lead to an overall decrease in disease incidence. To do this, we selected protein candidates expressed during biofilm growth based on their ability to elicit an IgA response in human serum. Selected proteins (SP_0459, SP_1114, and SP_1702) were identified and used for further experiments. The proteins identified in this study will be paired with other immunogenic proteins to determine a successful vaccine formulation targeting colonization of Streptococcus pneumoniae.
Travis, Amber, "Identifying pneumococcal proteins that elicit an IgA response" (2022). Theses and Dissertations. 5540.