Theses and Dissertations
Issuing Body
Mississippi State University
Advisor
Miralami, Raheleh
Committee Member
Sharma, Gehendra
Committee Member
Sharma, Gehendra
Committee Member
Stone, Tonya W.
Date of Degree
8-8-2023
Document Type
Graduate Thesis - Open Access
Major
Mechanical Engineering
Degree Name
Master of Science (M.S.)
College
James Worth Bagley College of Engineering
Department
Department of Mechanical Engineering
Abstract
Hydrocephalus is developed when the flow of cerebrospinal fluid is obstructed in the ventricles and a pressure build-up is generated within the brain. Ventricular shunts are used to remove excess fluid from the brain, but these shunts have a common problem of failure due to the shunt being obstructed by the build-up of astrocytes. To address this, two sets of 27 designs of ventricular shunts were identified and analyzed with parameters that could potentially reduce obstruction risks. The performance of these designs was examined using fluid simulations on these two sets of 27 designs. One set explored close-tipped shunt designs, and the other assessed open-tipped ones. Following these simulations, adjustments were made to three design variables of the ventricular catheters - inlet hole size, inner shunt diameter, and inner-segment distance. The goal was to optimize these variables to prevent obstruction, ensuring three key design objectives were met: maintaining wall shear stress, ensuring a balanced inlet and outlet pressure difference, and achieving a uniform flow distribution.
Recommended Citation
Kirkpatrick, Will, "Multi-objective design optimization of two configurations of ventricular shunts for hydrocephalus" (2023). Theses and Dissertations. 5871.
https://scholarsjunction.msstate.edu/td/5871