Mississippi State University
Hendrix, C. LaShan
To, Filip Suminto
Elder, Steven H.
Date of Degree
Graduate Thesis - Open Access
Master of Science (M.S.)
James Worth Bagley College of Engineering
Department of Agricultural and Biological Engineering
Cardiovascular disease is a significant health crisis, representing 32% of deaths worldwide in 2019. Vascular calcification (VC), a major contributor to cardiovascular disease, is a regulated biomineralization process whose exact mechanisms are unknown. Additionally, vascular smooth muscle cells (VSMCs) significantly contribute to VC by undergoing a phenotypic switch and differentiating into osteoblast-like cells. When factors like hypertension cause disturbed laminar flow in the body’s vasculature, the mechanical stress promotes the phenotypic switch and calcification of VSMCs via mechanotransduction. VC is also induced by the Wnt pathway, which is activated via mineral imbalance and mechanical stimulation. However, the exact mechanisms behind mechanotransduction in relation to VC, Wnt, and VSMC differentiation are unknown. If uncovered, knowledge of the mechanisms may be used to create effective treatments for VC.
Douglas, Hannah E., "The effects of mechanical strain on vascular calcification and the canonical Wnt pathway" (2023). Theses and Dissertations. 5882.