Theses and Dissertations

ORCID

https://orcid.org/0000-0001-7403-5255

Advisor

Fontenot, Robin L.

Committee Member

Betbeze, Caroline

Committee Member

Mochal-King, Cathleen Ann

Committee Member

Eddy, Alison L.

Date of Degree

5-10-2024

Original embargo terms

Immediate Worldwide Access

Document Type

Graduate Thesis - Open Access

Major

Veterinary and Biomedical Sciences (Veterinaty Medical Research)

Degree Name

Master of Science (M.S.)

College

College of Veterinary Medicine

Department

Department of Pathobiology and Population Medicine

Abstract

Corneal sensitivity and adverse events following subconjunctival administration of three local anesthetics in twelve mares were evaluated. The subconjunctival space of the treated eye was injected with 0.2 mL of mepivacaine (2%), ropivacaine (1.3%) and liposomal bupivacaine (1.3%). All horses received each medication once and the contralateral eye received saline. The corneal touch threshold (CTT) was measured using a esthesiometer before sedation, after sedation, and at specified intervals until it returned to baseline. The mean total time of anesthesia (TTA) was 168.3 minutes for ropivacaine, 169.2 minutes for liposomal bupivacaine, 103.3 minutes for mepivacaine and 30.7 minutes for control. The TTA for liposomal bupivacaine (P<0.001) and ropivacaine (P=0.001) was longer than the control. The TTA for mepivacaine was not different from the control (P = 0.138), liposomal bupivacaine (P = 0.075) or ropivacaine (P = 0.150). Injection site hemorrhage reduced TTA regardless of treatments (P=0.047). No adverse effects were noted.

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