Theses and Dissertations

ORCID

https://orcid.org/0009-0006-0966-0170

Advisor

Thornton, Justin A.

Committee Member

Gordon, Donna M.

Committee Member

Seo, Keun Seok

Committee Member

Park, Joo Youn

Date of Degree

5-10-2024

Original embargo terms

Visible MSU only 1 year

Document Type

Graduate Thesis - Campus Access Only

Major

Biological Sciences

Degree Name

Master of Science (M.S.)

College

College of Arts and Sciences

Department

Department of Biological Sciences

Abstract

Streptococcus pneumoniae (pneumococcus) is a commensal gram-positive colonizer of the human nasopharynx capable of causing diseases including otitis media, pneumonia, bacteremia, and meningitis. Although it is often a harmless colonizer, there is a high rate of mortality and morbidity among the immunocompromised, elderly, and young children. While these infections can often be treated with antibiotics, resistance to numerous antibiotics is increasing. Antibiotic resistance is a well-studied dilemma; however, little information is known of how bacteria take up certain antibiotics. Because most antibiotics cannot diffuse freely across the bacterial cell wall, we hypothesize that metabolite transport proteins participate in the uptake of certain classes of antibiotics.

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