Theses and Dissertations

ORCID

https://orcid.org/0000-0001-6487-8371

Advisor

Betbeze, Caroline

Committee Member

Telle, Mary Rebecca

Committee Member

Thomason, John

Committee Member

Fontenot, Robin

Date of Degree

5-10-2024

Original embargo terms

Immediate Worldwide Access

Document Type

Graduate Thesis - Open Access

Major

Veterinary and Biomedical Science (Veterinary Medical Research)

Degree Name

Master of Science (M.S.)

College

College of Veterinary Medicine

Department

Veterinary Medical Science Program

Abstract

Local anesthesia is critical for performing corneal procedures in horses. Studying non- ophthalmic local anesthetics for corneal use is necessary because the efficacy and availability of ophthalmic preparations may be limited. This study aimed to evaluate the effects and potential adverse consequences of ropivacaine hydrochloride 0.5% and lidocaine hydrochloride 2% when applied topically to the corneas of eight healthy equids compared to an eyewash control. Data collection occurred over one week. Corneal touch threshold (CTT) was assessed via Cochet-Bonnet esthesiometry before and at pre-determined times after medication application. Ocular toxicity was assessed immediately following each trial and prior to the second trial using the semiquantitative preclinical ocular toxicity system (SPOTS). Ropivacaine and lidocaine significantly reduced CTT from baseline values. However, mean CTT and time to maximum anesthesia were not significantly different between drugs. No local side effects were seen. Ropivacaine and lidocaine could be used topically to reduce corneal sensitivity.

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