Theses and Dissertations
Issuing Body
Mississippi State University
Advisor
Thomason, John M.
Committee Member
Mackin, Andrew J.
Committee Member
Eubanks, Diana L.
Committee Member
Archer, Todd M.
Committee Member
Langston, V. Cory
Date of Degree
5-1-2020
Original embargo terms
Worldwide
Document Type
Graduate Thesis - Open Access
Major
Veterinary Medical Science
Degree Name
Master of Science
College
College of Veterinary Medicine
Department
Veterinary Medical Science Program
Abstract
Enoxaparin, a low-molecular-weight heparin, is commonly used as an anticoagulant in dogs, and is currently dosed at 0.8mg/kg every 6 hours. With an increase in individual enoxaparin doses, less frequent dosing may be possible, thereby reducing owner inconvenience and expense. The three phases of this study investigated the appropriate dose (Phase one- 0.8mg/kg, SQ once; Phase two- 2mg/kg, SQ once; Phase three- 1.3 mg/kg, SQ q8h for 7 total doses) and dosing interval needed for maximum effectiveness of enoxaparin. A Sonoclot® analyzer and factor Xa activity were used to assess level of anticoagulation in six healthy dogs. Anticoagulation was inconsistent at the 0.8mg/kg dose, while the 2mg/kg dose showed a high level of anticoagulation, and the 1.3mg/kg dose provided more reliable anticoagulation than the other dosages and dosing intervals. Small sample size and the use of same-breed healthy dogs potentially affected the strength of the results.
URI
https://hdl.handle.net/11668/16960
Sponsorship
None
Recommended Citation
Frum, Julianna, "Anticoagulant profile of subcutaneous enoxaparin in healthy dogs" (2020). Theses and Dissertations. 688.
https://scholarsjunction.msstate.edu/td/688