Theses and Dissertations

ORCID

https://orcid.org/0009-0003-2993-7569

Advisor

Betbeze, Caroline

Committee Member

Thomason, John

Committee Member

Telle, Mary

Date of Degree

5-15-2026

Original embargo terms

Immediate Worldwide Access

Document Type

Graduate Thesis - Open Access

Major

Veterinary & Biomedical Science (Veterinary Medical Research)

Degree Name

Master of Science (M.S.)

College

College of Veterinary Medicine

Department

College of Veterinary Medicine

Abstract

To determine plasma concentrations of ophthalmic 0.1% (w/v) diclofenac sodium and 0.5% (w/v) ketorolac tromethamine following 4 times daily ophthalmic administration in healthy dogs. Eight dogs were randomly assigned to a diclofenac or ketorolac group. Plasma was collected before drug administration. Plasma samples were collected after the 4 pm treatments on days 1 and 5. Plasma concentrations (ng/mL) were quantified by liquid chromatography-mass spectrometry and analyzed with noncompartmental pharmacokinetic analysis. After ophthalmic administration of 0.1% diclofenac, mean t1/2, Tmax, and Cmax occurred at 3.08 0.9 hours, 121.4 2.8 hours, 0.12 0.05 ug/mL, respectively. The mean t1/2, Tmax, and Cmax after 0.5% ketorolac administration were 18.5 14.6 hours, 121.6 2.0 hours, 1.8 1.7 ug/mL, respectively. The AUC for diclofenac and ketorolac was 8.97 3.73 ug/mlh and 98.2 43.3 ug/ml/h, respectively. Diclofenac and ketorolac were rapidly absorbed systemically after ophthalmic administration. The half-life of topical ketorolac is six times longer than that of diclofenac.

Sponsorship (Optional)

Mississippi State University Office of Research and Graduate Studies Internal Grant Program Research Fund

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