Theses and Dissertations

Issuing Body

Mississippi State University

Advisor

McLaughlin, Ronald

Committee Member

Cooper, Robert

Committee Member

Elder, Steven

Date of Degree

12-10-2005

Document Type

Graduate Thesis - Open Access

Major

Veterinary Medical Science

Degree Name

Master of Science

College

College of Veterinary Medicine

Department

Department of Clinical Sciences

Abstract

The effects caused to articular cartilage by the remote use of arthroscopically-delivered RF energy to soft tissues in the joint are unknown. This investigation reported the short and long-term effects of bRF and mRF energy on the biomechanical properties and metabolic activity of articular cartilage. In addition, the effect of Cosequin® therapy was addressed. Thirty New Zealand white rabbits were randomly assigned to one of two treatment groups (Group 1 - placebo; Group 2 - Cosequin®). Histopathology, cell viability, GAG synthesis, and mechanical function of the articular cartilage were compared between groups. Data were analyzed using a mixed model ANOVA (p=0.05). Immediate chondrocyte death was created by both RF devices. This damage was noted to be superficial and did not lead to the progressive deterioration of the extracellular matrix or mechanical function of the articular cartilage. Cosequin® therapy was unable to demonstrate significant differences compared to the control group.

URI

https://hdl.handle.net/11668/17362

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