Effects of Bed Bug Saliva on Human Skin

ORCID

Goddard: https://orcid.org/0000-0002-2617-7141

MSU Affiliation

College of Agriculture and Life Sciences; Department of Biochemistry, Molecular Biology, Entomology and Plant Pathology

Creation Date

2026-10-30

Abstract

Bed bug infestations are increasing in scope, frequency, and geographic distribution worldwide, and bed bug bites should be included in the differential diagnosis in cases of unexplained or cryptic insect bites and anaphylactoid reactions.1-4 Some patients apparently develop sensitivity to bed bug bites, while others do not.5,6 The nature, type, and location of allergens in bed bugs causing dermatologic reactions in humans have not been elucidated. Presumably, bed bug allergens are located in the saliva. With appropriate institutional review board approval, we tested that hypothesis, feeding bed bugs, both with and without intact salivary glands, on a volunteer known to react to the bites.

Publication Date

3-1-2013

Publication Title

JAMA Dermatology

Publisher

Taylor and Francis Group; Taylor and Francis

First Page

372

Last Page

373

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Digital Object Identifier (DOI)

https://doi.org/10.1001/jamadermatol.2013.878