Evaluation of Marijuana Compounds on Neuroimmune Endpoints in Experimental Autoimmune Encephalomyelitis

ORCID

Kaplan: https://orcid.org/0000-0002-1992-4145

MSU Affiliation

College of Veterinary Medicine; Department of Basic Sciences; Center for Environmental Health Sciences

Creation Date

2026-03-30

Abstract

Cannabinoid compounds refer to a group of more than 60 plant-derived compounds in Cannabis sativa, more commonly known as marijuana. Exposure to marijuana and cannabinoid compounds has been increasing due to increased societal acceptance for both recreational and possible medical use. Cannabinoid compounds suppress immune function, and while this could compromise one's ability to fight infections, immune suppression is the desired effect for therapies for autoimmune diseases. It is critical, therefore, to understand the effects and mechanisms by which cannabinoid compounds alter immune function, especially immune responses induced in autoimmune disease. Therefore, this unit will describe induction and assessment of the experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis (MS), and its potential alteration by cannabinoid compounds. The unit includes three approaches to induce EAE, two of which provide correlations to two forms of MS, and the third specifically addresses the role of autoreactive T cells in EAE. © 2018 by John Wiley & Sons, Inc.

Publication Date

2-21-2018

Publication Title

Current Protocols in Toxicology

Publisher

Wiley

First Page

11.25.1

Last Page

11.25.22

Link to Full Text

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Digital Object Identifier (DOI)

https://doi.org/10.1002/cptx.43