Honors Theses

College

College of Agriculture and Life Sciences

Department

Department of Food Science, Nutrition and Health Promotion

Degree

Bachelor of Science (B.S.)

Document Type

Honors Thesis

Abstract

The onset of type 2 diabetes has been shown to affect the Akt signaling pathway, responsible for modulating cellular metabolism. The pro biotic Akkermensia muciniphilia has been recently shown to have an anti-inflammatory, anti-diabetic effect on animals inoculated with it, particularly within the Akt signaling pathway. This preliminary study utilized a twofactor experimental design with streptozotocin-induced diabetes and the presence of Akkermensia muciniphila in pig models in order to elucidate the probiotic's mechanism of action on the disease. Following analysis of insulin-sensitive tissues of muscle, pancreas, and liver, there was observed a mixed response to the presence of the probiotic and diabetes separately and together in the three tissues. This leaves open the possibility of the use of the probiotic as a preventative measure for diabetes.

Publication Date

1-1-2019

First Advisor

Cheng, Wen-Hsing

Second Advisor

Zhang, Li

Third Advisor

Elder, Anastasia

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