Degree
Bachelor of Science (B.S.)
Major(s)
Biological Engineering
Document Type
Immediate Open Access
Abstract
The onset of type 2 diabetes has been shown to affect the Akt signaling pathway, responsible for modulating cellular metabolism. The pro biotic Akkermensia muciniphilia has been recently shown to have an anti-inflammatory, anti-diabetic effect on animals inoculated with it, particularly within the Akt signaling pathway. This preliminary study utilized a twofactor experimental design with streptozotocin-induced diabetes and the presence of Akkermensia muciniphila in pig models in order to elucidate the probiotic's mechanism of action on the disease. Following analysis of insulin-sensitive tissues of muscle, pancreas, and liver, there was observed a mixed response to the presence of the probiotic and diabetes separately and together in the three tissues. This leaves open the possibility of the use of the probiotic as a preventative measure for diabetes.
DOI
https://doi.org/10.54718/RREX7221
Date Defended
1-1-2019
Thesis Director
Cheng, Wen-Hsing
Second Committee Member
Zhang, Li
Third Committee Member
Elder, Anastasia
Recommended Citation
Ko, Brian, "Preliminary study on the effects of Akkermensia muciniphilia on Akt phosphorylation in diabetic pig models" (2019). Honors Theses. 64.
https://scholarsjunction.msstate.edu/honorstheses/64
