College of Agriculture and Life Sciences
Department of Food Science, Nutrition and Health Promotion
Bachelor of Science (B.S.)
The onset of type 2 diabetes has been shown to affect the Akt signaling pathway, responsible for modulating cellular metabolism. The pro biotic Akkermensia muciniphilia has been recently shown to have an anti-inflammatory, anti-diabetic effect on animals inoculated with it, particularly within the Akt signaling pathway. This preliminary study utilized a twofactor experimental design with streptozotocin-induced diabetes and the presence of Akkermensia muciniphila in pig models in order to elucidate the probiotic's mechanism of action on the disease. Following analysis of insulin-sensitive tissues of muscle, pancreas, and liver, there was observed a mixed response to the presence of the probiotic and diabetes separately and together in the three tissues. This leaves open the possibility of the use of the probiotic as a preventative measure for diabetes.
Ko, Brian, "Preliminary study on the effects of Akkermensia muciniphilia on Akt phosphorylation in diabetic pig models" (2019). Honors Theses. 64.