Efficacy of Novel Pyridinium Oximes in Preventing Neural Damage

Author

Charles Andrew Leach

Issuing Body

Mississippi State University

Advisor

Chambers, Janice E.

Committee Member

Carr, Russell L.

Committee Member

Olivier, Alicia K.

Date of Degree

12-8-2017

Document Type

Graduate Thesis - Open Access

Major

Veterinary Medical Science

Degree Name

Master of Science (M.S.)

College

College of Veterinary Medicine

Department

Veterinary Medical Science Program

Abstract

Organophosphates are neurotoxic compounds that inhibit acetylcholinesterase producing excess cholinergic stimulation. This produces various toxic signs including excitotoxic neuronal damage. Oximes can be used as a treatment for organophosphate poisoning by reactivating inhibited acetylcholinesterase. Traditional oximes do not penetrate the blood-brain barrier, limiting protection of the central nervous system. Novel, brain-penetrating oximes have the potential to protect the brain from organophosphate induced damage. Adult male rats were used to examine the ability of model organophosphates to produce neuropathology and the ability of novel oximes to prevent this damage. Additionally, adult male rats were used to examine changes in gene expression of the MAP kinase system resultant of treatment with model organophosphates and novel oximes. Results of these experiments support that the model organophosphates can be used to study neurodegeneration, the novel oximes may prevent neurodegeneration, and both organophosphates and novel oximes affect expression of MAP kinase genes.

URI

https://hdl.handle.net/11668/18497

Recommended Citation

Leach, Charles Andrew, "Efficacy of Novel Pyridinium Oximes in Preventing Neural Damage" (2017). Theses and Dissertations. 1832.
https://scholarsjunction.msstate.edu/td/1832