Theses and Dissertations
Issuing Body
Mississippi State University
Advisor
Gambino, Jennifer M.
Committee Member
Brinkman, Erin
Committee Member
Syrcle, Jason
Committee Member
Beasley, Michaela
Date of Degree
5-6-2017
Original embargo terms
Worldwide
Document Type
Graduate Thesis - Open Access
Major
Veterinary Medicine Research
Degree Name
Master of Science
College
College of Veterinary Medicine
Department
Veterinary Medical Science Program
Abstract
Proton MR spectroscopy is a tool that provides quantified brain bioprofiles. Two methods exist: single- and multi-voxel spectroscopy. No studies compare their clinical validity in vivo. Gadolinium based MR contrast agents are used to improve lesional conspicuity. Adverse events are reported. Brain deposition occurs following administration in people and murine models. In dogs, doses are anecdotal and deposition is not described. Eight normal dogs underwent MRI at 3 Tesla with two methods of spectroscopy and were administered varying doses of gadodiamide. No differences were seen between single- and multi-voxel spectroscopy when interrogating identical regions of interest. Brains were harvested and evaluated for gadolinium depots using inductively coupled plasma mass spectrometry. Gadolinium was found in the brains of all dogs with dose dependency. Further, adequate normal brain conspicuity was seen at a dose of 0.5 mmol/kg. Thus, clinical trials of gadolinium chelated contrast agents at this dose are recommended.
URI
https://hdl.handle.net/11668/17604
Recommended Citation
Lee, Alison Margret, "Neuronal Tissue Deposition of Gadolinium following Single in Vivo Intravenous Exposure of Low Doses Of Gadodiamide In the Brains of Healthy Dogs and Comparison of Single- And Multi-Voxel Spectroscopy in the Normal Canine Brain at 3 Tesla" (2017). Theses and Dissertations. 3281.
https://scholarsjunction.msstate.edu/td/3281
Comments
comparison||multi-voxel||brain||gadolinium||chelated||deposition||single-voxel||spectroscopy||canine||MRI||adverse event||dose dependent