Theses and Dissertations

Issuing Body

Mississippi State University

Advisor

Mathews, Rahel

Committee Member

Tolar-Peterson, Terezie

Committee Member

Conrad, Amanda

Date of Degree

5-12-2023

Document Type

Graduate Thesis - Campus Access Only

Major

Nutrition

Degree Name

Master of Science (M.S.)

College

College of Agriculture and Life Sciences

Department

Department of Food Science, Nutrition and Health Promotion

Abstract

Traumatic brain injuries (TBI) are a leading cause of death worldwide. Previous research supports a relationship between vitamin D and TBI outcomes; however, they rely on animal studies. This review aimed to examine the neuroprotective role of vitamin D in humans with TBIs. A search was completed (PubMed and Scopus) following PRISMA guidelines to review publications investigating the relationship between vitamin D deficiency (VDD) and TBI or the effect of vitamin D supplementation on TBI outcomes; 8 studies were identified. Patients had the
following ranges: 26-88% deficiency and 62-88% insufficiency compared to 24% and 49% of the general population. Supplementation reduced ventilation duration, improved the quality of consciousness, and significantly improved mini-mental status examination scores. Research showed high percentages VDD/insufficiency in TBI patients. Results remain consistent suggesting a neuroprotective effect of vitamin D. Further research is needed to understand the effect of vitamin D status and supplementation on TBIs.

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