Theses and Dissertations

ORCID

https://orcid.org/0000-0003-3056-1813

Issuing Body

Mississippi State University

Advisor

Meyer, Florencia

Committee Member

Hoffmann, Federico G.

Committee Member

Nanduri, Bindu

Committee Member

Thornton, Justin A.

Date of Degree

12-8-2023

Original embargo terms

Campus Access Only 2 Years

Document Type

Dissertation - Campus Access Only

Major

Molecular Biology

Degree Name

Doctor of Philosophy (Ph.D)

College

College of Agriculture and Life Sciences

Department

Department of Biochemistry, Molecular Biology, Entomology and Plant Pathology

Abstract

Bovine respiratory disease (BRD) costs the cattle industry millions of dollars in costs in treatment and loss every year in the United States. A significant pathogen often contributes to BRD is Bovine Herpesvirus 1 (BoHV-1), a double stranded DNA virus with the ability to establish latency in the trigeminal ganglia and neurons. Primary infection with BoHV-1 results in immunosuppression that increases the risk of secondary bacterial infection and pneumonia. Because herpesviruses infect their hosts for life and can be reactivated in times of stress, BoHV-1 can present a recurring risk of BRD. The following research aims to expand the knowledge of the genome of this costly agricultural pathogen and provide evidence of viral features that can be further explored to increase the efficiency of its control.

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