Theses and Dissertations

Issuing Body

Mississippi State University


Mathews, Rahel

Committee Member

Tolar-Peterson, Terezie

Committee Member

Conrad, Amanda

Date of Degree


Document Type

Graduate Thesis - Campus Access Only



Degree Name

Master of Science (M.S.)


College of Agriculture and Life Sciences


Department of Food Science, Nutrition and Health Promotion


Traumatic brain injuries (TBI) are a leading cause of death worldwide. Previous research supports a relationship between vitamin D and TBI outcomes; however, they rely on animal studies. This review aimed to examine the neuroprotective role of vitamin D in humans with TBIs. A search was completed (PubMed and Scopus) following PRISMA guidelines to review publications investigating the relationship between vitamin D deficiency (VDD) and TBI or the effect of vitamin D supplementation on TBI outcomes; 8 studies were identified. Patients had the
following ranges: 26-88% deficiency and 62-88% insufficiency compared to 24% and 49% of the general population. Supplementation reduced ventilation duration, improved the quality of consciousness, and significantly improved mini-mental status examination scores. Research showed high percentages VDD/insufficiency in TBI patients. Results remain consistent suggesting a neuroprotective effect of vitamin D. Further research is needed to understand the effect of vitamin D status and supplementation on TBIs.